abstract：BACKGROUND:Gas6 protein is involved in pulmonary embolism (PE) and acute inflammation in animal models. METHODS:We enrolled 82 consecutive patients with acute dyspnea and suspected PE (Geneva score with high (HCP) or low/intermediate clinical probability (LICP)+D-dimer >or=0.5microg/mL) and 29 age-matched healthy volu...

journal_title：Respiratory medicine

authors： Sainaghi PP,Alciato F,Carnieletto S,Castello L,Bergamasco L,Sola D,Bongo AS,Inglese E,Polosa R,Avanzi GC

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea (OSA) is emerging as a significant disorder in India. Tumor necrosis factor-alpha (TNFalpha) is an important marker of inflammation. Recent data indicate that inflammation may be an important correlate of OSA. The relationships of OSA with TNFalpha levels and TNFalpha gene promoter po...

journal_title：Respiratory medicine

authors： Bhushan B,Guleria R,Misra A,Luthra K,Vikram NK

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Although athletes have a high prevalence of airway hyperresponsiveness (AHR) and asthma, little is known about possible gender differences in regard to these features. We looked at the comparative prevalence of AHR, physician-diagnosed asthma and respiratory symptoms during exercise in female (F) and male (M...

journal_title：Respiratory medicine

authors： Langdeau JB,Day A,Turcotte H,Boulet LP

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Previous investigations have suggested that genetic variations are associated with reduced lung function in early childhood. This study was conducted to evaluate the association between IL13+2044G-->A, the functionally relevant single nucleotide polymorphism (SNP) in the gene coding IL13, and lung function i...

journal_title：Respiratory medicine

authors： Park HW,Lee JE,Kim SH,Kim YK,Min KU,Kim YY,Cho SH

更新日期：2009-02-01 00:00:00

abstract：:Pulmonary hypertension is a relevant interceding morbidity in patients with pulmonary fibrosis that has significant impact on exercise tolerance and outcome. The aim of this study was to further characterize the exercise intolerance, dyspnoea and ventilatory inefficiency of patients with pulmonary fibrosis in the pres...

journal_title：Respiratory medicine

authors： Gläser S,Noga O,Koch B,Opitz CF,Schmidt B,Temmesfeld B,Dörr M,Ewert R,Schäper C

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Nitrite in exhaled breath condensate (EBC) has been shown to be elevated in cystic fibrosis (CF), while exhaled nitric oxide (FENO) is paradoxically low. This has been argued to reflect increased metabolism of NO while its diffusion is obstructed by mucus. However, we wanted to study the possible influence o...

journal_title：Respiratory medicine

authors： Zetterquist W,Marteus H,Kalm-Stephens P,Näs E,Nordvall L,Johannesson M,Alving K

更新日期：2009-02-01 00:00:00

abstract：:The present study investigated, for the first time, the long-term prognosis of hypersensitivity type of occupational laryngitis (OL). Thirteen patients with OL diagnosed in 1990-1993 at the Finnish Institute of Occupational Health participated in a questionnaire follow-up study. The records of the primary diagnostic i...

journal_title：Respiratory medicine

authors： Hannu T,Sala E,Toskala E

更新日期：2009-01-01 00:00:00

abstract：:Hypoxemic patients with chronic obstructive pulmonary disease (COPD) are at risk of carbon dioxide (CO(2)) retention during oxygen therapy and hypercapnia in COPD is associated with an ominous prognosis. Rebreathing with oxygen mask is possible in practice and possibly affects CO(2) retention due to an increased inspi...

journal_title：Respiratory medicine

authors： Fremault A,Silva M,Beaucage F,Berckmans D,Decramer M

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:The presence of non-reversible airway obstruction (AO) in never smokers has only received limited attention until now. METHODS:We analyzed data from the Austrian Burden of Obstructive Lung Disease (BOLD) study. We defined non-reversible AO as post-bronchodilator FEV(1)/FVC <0.7 which corresponds to COPD I a...

journal_title：Respiratory medicine

authors： Lamprecht B,Schirnhofer L,Kaiser B,Buist S,Studnicka M

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Intrapleural recombinant tissue plasminogen activator (r-TPA) has been successfully evaluated in pediatric patients with complicated parapneumonic pleural effusion (CPE) and pleural empyema (PE). Yet, there is no data concerning r-TPA in adults with CPE/PE. The aim of our study was to investigate the efficac...

journal_title：Respiratory medicine

authors： Froudarakis ME,Kouliatsis G,Steiropoulos P,Anevlavis S,Pataka A,Popidou M,Mikroulis D,Pneumatikos I,Bouros D

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Data on the effects of long-term treatment with azithromycin (AZM) on inflammatory markers in cystic fibrosis patients chronically infected with Pseudomonas aeruginosa are scarce. So far there is no pharmacokinetic and clinical data on once-weekly dosage of AZM in CF patients. METHODS:In a randomised double...

journal_title：Respiratory medicine

authors： Steinkamp G,Schmitt-Grohe S,Döring G,Staab D,Pfründer D,Beck G,Schubert R,Zielen S

更新日期：2008-11-01 00:00:00

abstract：:In an attempt to guide physicians asked by respiratory patients for advice on flight fitness, the British Thoracic Society (BTS) have published guidelines on fitness to fly. The main potential hazard is hypobaric hypoxia, and efforts have focused on the prediction of hypoxia in individuals. The present study examines ...

journal_title：Respiratory medicine

authors： Robson AG,Lenney J,Innes JA

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Although sarcoidosis most commonly affects the lungs, it is a multisystemic disease that often involves other organs. In this study, we compared fatigue, dyspnea, and the impact upon the activities of daily living and health status scores between patients with isolated pulmonary and pulmonary plus extrapulmo...

journal_title：Respiratory medicine

authors： Gvozdenovic BS,Mihailovic-Vucinic V,Ilic-Dudvarski A,Zugic V,Judson MA

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:Local and systemic inflammation is implicated in the pathophysiology of Obstructive Sleep Apnea (OSA). Exhaled breath condensate (EBC) is a non-invasive sampling method for the lower airways. However, it is important to consider the potential effect of the systemic origin whereas systemic inflammation is sig...

journal_title：Respiratory medicine

authors： Antonopoulou S,Loukides S,Papatheodorou G,Roussos C,Alchanatis M

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:In a 1-year, randomized, open-label study in patients with moderate-to-severe allergic (immunoglobulin E (IgE)-mediated) asthma, adding omalizumab to best standard care (BSC) significantly improved efficacy outcomes compared with BSC alone (control). We assessed the efficacy of omalizumab in the subgroup of ...

journal_title：Respiratory medicine

authors： Niven R,Chung KF,Panahloo Z,Blogg M,Ayre G

更新日期：2008-10-01 00:00:00

abstract：INTRODUCTION:Exhaled nitric oxide (FE(NO)) is a reliable non-invasive marker of airway inflammation. In 2003 FE(NO) chemiluminescence analyzer (NIOX; Aerocrine AB, Solna, Sweden) was approved by U.S. Food and Drug Administration for monitoring asthma therapy. Recently, the same company developed a portable device using...

journal_title：Respiratory medicine

authors： Pizzimenti S,Bugiani M,Piccioni P,Heffler E,Carosso A,Guida G,Rolla G

更新日期：2008-09-01 00:00:00

abstract：:RANTES has been implicated in the allergic inflammation of asthma by promoting the migration and activation of the inflammatory cells, including eosinophils. The study was undertaken to evaluate RANTES levels in the exhaled breath condensate (EBC) of asthmatics with different degrees of asthma severity. EBC was collec...

journal_title：Respiratory medicine

authors： Zietkowski Z,Tomasiak MM,Skiepko R,Bodzenta-Lukaszyk A

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:To improve physicians' ability to discriminate tuberculous from malignant pleural effusions through a simple clinical algorithm that avoids pleural biopsy. DESIGN:We retrospectively compared the clinical and pleural fluid features of 238 adults with pleural effusion who satisfied diagnostic criteria for tube...

journal_title：Respiratory medicine

authors： Porcel JM,Alemán C,Bielsa S,Sarrapio J,Fernández de Sevilla T,Esquerda A

更新日期：2008-08-01 00:00:00

abstract：:Measurement of exhaled nitric oxide is widely used in respiratory research and clinical practice, especially in patients with asthma. However, interpretation is often difficult, due to common interfering factors, and little is known about interactions between factors. We assessed the influences and interactions of fac...

journal_title：Respiratory medicine

authors： Dressel H,de la Motte D,Reichert J,Ochmann U,Petru R,Angerer P,Holz O,Nowak D,Jörres RA

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:The optimal initial management of primary spontaneous pneumothorax (PSP) remains controversial. This study was to evaluate the safety and efficacy of intrapleural minocycline following aspiration for initial treatment of PSP. METHODS:Between January 2004 and November 2006, 64 patients with a first episode o...

journal_title：Respiratory medicine

authors： Chen JS,Tsai KT,Hsu HH,Yuan A,Chen WJ,Lee YC

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Recent studies have shown strong evidence that bronchiolitis obliterans is the major long-term sequelae of exposure to sulfur mustard (SM). This study is the first to examine the histopathologic spectrum of changes in a large number of surgical lung biopsies from patients exposed to SM. METHOD:Fifteen patie...

journal_title：Respiratory medicine

authors： Ghanei M,Tazelaar HD,Chilosi M,Harandi AA,Peyman M,Akbari HM,Shamsaei H,Bahadori M,Aslani J,Mohammadi A

更新日期：2008-06-01 00:00:00

abstract：:Clinically there are several different types of eosinophilic pneumonia (EP), but other than for tropical pulmonary eosinophilia, the humoral immune response between different types of EP, such as acute eosinophilic pneumonia (AEP), chronic EP, drug-induced EP, allergic bronchopulmonary aspergillosis, and Churg-Strauss...

journal_title：Respiratory medicine

authors： Matsuno O,Takenaka R,Hiroshige S,Ono E,Nishitake T,Ueno T,Miyazaki E,Kumamoto T

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:The possible effect of the various meteorological variables on the incidence of upper and lower respiratory tract infections (RTIs) has intrigued the scientific community for decades. METHODS:We performed a retrospective analysis regarding the association between meteorological variables and clinical data fo...

journal_title：Respiratory medicine

authors： Falagas ME,Theocharis G,Spanos A,Vlara LA,Issaris EA,Panos G,Peppas G

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Long-term follow-up after transition to oral agents from parenteral prostanoid therapy has not been well characterized. METHODS:We reviewed our long-term experience after oral transitioning in patients with pulmonary hypertension. Patients were weaned off parenteral therapy based on a pre-determined outpati...

journal_title：Respiratory medicine

authors： Diaz-Guzman E,Heresi GA,Dweik RA,Minai OA

更新日期：2008-05-01 00:00:00

abstract：:Report of an incidental chest X-ray finding of a large vessel dilation at the root of the ascending aorta in a 65-year-old female patient while pre-operative routine diagnostic. Due to prior allergic reaction to iodine contrast agent, non-invasive imaging was performed with magnetic resonance imaging (MRI), where the ...

journal_title：Respiratory medicine

authors： Ritter CO,Weininger M,Machann M,Beissert M,Hahn D,Kenn W

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Although baker's asthma (BA) is a common occupational asthma, there have been few reports on this disease in Korean subjects. OBJECTIVES:We evaluated the prevalence of serum-specific IgE, IgG1, and IgG4 antibodies in relation to work-related respiratory symptoms in a single industrial bakery. METHODS:Three...

journal_title：Respiratory medicine

authors： Hur GY,Koh DH,Kim HA,Park HJ,Ye YM,Kim KS,Park HS

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) severity is usually graded upon the FEV(1) reduction and FEV(1) has been considered the most important mortality predictor with age in COPD. Recent studies suggest other factors as more powerfully related to mortality than FEV(1) in COPD patients. AIM:To assess t...

journal_title：Respiratory medicine

authors： Tantucci C,Donati P,Nicosia F,Bertella E,Redolfi S,De Vecchi M,Corda L,Grassi V,Zulli R

更新日期：2008-04-01 00:00:00

abstract：:Given the high prevalence of chronic obstructive pulmonary disease (COPD), the impact of exacerbations on quality of life, and the costs incurred, effective ways for the prevention of exacerbations, and for reductions in the severity and duration of COPD symptoms are needed. Bacterial immunostimulation has been advoca...

journal_title：Respiratory medicine

authors： Cazzola M,Rogliani P,Curradi G

更新日期：2008-03-01 00:00:00

abstract：:In recent years, it has become increasingly important to get as much as possible information on clinical efficacy already in the early phases of drug development. For proof of concept (POC) studies testing novel anti-inflammatory drugs in asthma, there are several validated exacerbation models, inducing various aspect...

journal_title：Respiratory medicine

authors： Diamant Z,Boot D,Kamerling I,Bjermer L

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Apoptosis is thought to play an important role in the development of acute respiratory distress syndrome (ARDS). We evaluated the bronchoalveolar lavage (BAL) fluid from ARDS patients focusing on apoptosis. METHODS:The study enrolled 31 ARDS patients and 20 healthy controls. BAL fluid levels of caspase-clea...

journal_title：Respiratory medicine

authors： Lee KS,Choi YH,Kim YS,Baik SH,Oh YJ,Sheen SS,Park JH,Hwang SC,Park KJ

更新日期：2008-03-01 00:00:00

abstract：:The differential diagnosis of pleural masses is limited. Asbestos-related disease and invasive bronchogenic carcinoma make up the majority of cases. The diagnostic yield of biopsies is low, and invasive procedures are often required to achieve diagnosis. A variety of imaging techniques are available to help differenti...

journal_title：Respiratory medicine

authors： Bruns AS,Mastronarde JG

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Mycobacterium tuberculosis has been proposed as a candidate agent for the cause of sarcoidosis. The QuantiFERON-TB Gold test has a higher specificity for detecting M. tuberculosis infection than the conventional tuberculin skin test. This study aimed to investigate the rate of positive QuantiFE...

journal_title：Respiratory medicine

authors： Inui N,Suda T,Chida K

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Given the observed association between smoking, inflammation and airway hyperresponsiveness (AHR) one may predict that smoking cessation may improve AHR. However, only a few studies have investigated the effect of smoking on AHR and their results appear to be conflicting depending on the stimulus used in the...

journal_title：Respiratory medicine

authors： Piccillo G,Caponnetto P,Barton S,Russo C,Origlio A,Bonaccorsi A,Di Maria A,Oliveri C,Polosa R

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Anti-endothelial cell antibodies (AECA) are circulating antibodies that bind to endothelial antigens and induce endothelial cell damage. AECA have been detected in patients with collagen vascular disease (CVD) and their presence is associated with interstitial lung disease (ILD) in cases of CVD. However, the...

journal_title：Respiratory medicine

authors： Matsui T,Inui N,Suda T,Chida K

更新日期：2008-01-01 00:00:00

abstract：:Bronchial asthma is a costly disease and the correlated social impact is ever increasing. The aim of the Social Impact of Respiratory Integrated Outcomes (SIRIO) study was to measure the health resources consumption and the costs generated in 1 year by asthmatic patients investigated in a real-life setting. This botto...

journal_title：Respiratory medicine

authors： Dal Negro RW,Micheletto C,Tosatto R,Dionisi M,Turco P,Donner CF

更新日期：2007-12-01 00:00:00

abstract：:The aim of our study was to evaluate the utility of interrupter resistance (R(int)), transcutaneous oximetry and auscultation as outcome measures for a recently suggested tripling-dose methacholine (Mch) challenge in pre-school children. We studied 57 children aged 3-6 years. R(int) was measured at baseline and after ...

journal_title：Respiratory medicine

authors： Kivastik J,Gibson AM,Primhak RA

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Having a child with a chronic disease may cause anxiety and depression and impair the sleep quality in the mothers. The aim of this study was to evaluate sleep quality in asthmatic children and their mothers as well as the status of anxiety-depression in the mothers. METHODS:Study group consisted of 75 asth...

journal_title：Respiratory medicine

authors： Yuksel H,Sogut A,Yilmaz O,Demet M,Ergin D,Kirmaz C

更新日期：2007-12-01 00:00:00

abstract：STUDY OBJECTIVES:Community-acquired pneumonia is a frequent event in the course of chronic obstructive pulmonary disease (COPD). The aim of the present study was to provide information on clinical and microbiological characteristics and outcome of community-acquired pneumonia in these patients, in a comparative study w...

journal_title：Respiratory medicine

authors： Pifarre R,Falguera M,Vicente-de-Vera C,Nogues A

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:Sarcoidosis (SA) is a multisystem granulomatous disorder of unknown etiology. It seems likely that in genetically different predisposed hosts, the same antigen(s) may cause the development of sarcoid Th1 response. The interaction of the T-cell receptor with the human leukocyte antigen-DQA1*03011 peptide-comp...

journal_title：Respiratory medicine

authors： Dubaniewicz A,Dubaniewicz A,Dubaniewicz A,Moszkowska G

更新日期：2007-10-01 00:00:00

abstract：BACKGROUND:The aim of the study was to investigate the efficacy and safety of ciclesonide compared with budesonide in adolescents with severe asthma. METHODS:In this randomized, double-blind, double-dummy, parallel-group study, patients aged 12-17 years with severe asthma were treated with budesonide 400 microg once d...

journal_title：Respiratory medicine

authors： Vermeulen JH,Gyurkovits K,Rauer H,Engelstätter R

更新日期：2007-10-01 00:00:00